THE DEBATE ABOUT DEATH: AN IMPERISHABLE DISCUSSION?

The debate about death: an imperishable discussion?

In this concise review we discuss some of the complex edges of the concept of death that arose after the notorious advances in science and medicine over the last 50 years, in which the classical cardio-pulmonary criteria have led to the neurological criteria of death.New complicated questions like the definition of death and the operational criteri

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Substrate-induced unfolding of protein disulfide isomerase displaces the cholera toxin A1 subunit from its holotoxin.

To generate a cytopathic effect, the catalytic A1 subunit of cholera toxin (CT) must be separated from the rest of the toxin.Protein disulfide isomerase (PDI) is thought to mediate CT disassembly by acting as a redox-driven chaperone that actively unfolds the CTA1 subunit.Here, we show that PDI itself unfolds upon contact with CTA1.The substrate-in

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